Neuroprotective effects of glial cell line-derived neurotrophic factor (GDNF) against ischemia-induced brain injury
نویسندگان
چکیده
منابع مشابه
increased expression of glial cell line-derived neurotrophic factor in rat brain after traumatic brain injury
glial cell line-derived neurotrophic factor (gdnf) plays important roles not only for the differentiation of neurons during normal development but also for the survival and recovery of many populations of mature neurons. the effect of traumatic brain injury (tbi) on the expression of gdnf is currently unknown. to determine if there is alteration in gdnf after tbi we examined the effect of contr...
متن کاملGlial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex.
Glial cell line-derived neurotrophic factor (GDNF), a recently described and cloned member of the transforming growth factor (TGF)-beta superfamily, has been shown to have marked trophic activity on several populations of central neurons. Survival-promoting and injury protectant activity in vitro and in vivo, using several paradigms, has been demonstrated for ventral mesencephalic dopaminergic ...
متن کاملThe Effects of Progesterone on Glial Cell Line-derived Neurotrophic Factor Secretion from C6 Glioma Cells
Objective(s)Progesterone is a steroid hormone whose biology has been greatly studied within the confines of reproductive function. In recent years, the neuroprotective effects of progesterone have attracted growing interest. Glial cell line-derived neurotrophic factor (GDNF), is a neurotrophic factor which plays a crucial role in the development and maintenance of distinct sets of central and p...
متن کاملEffects of Glial Cell Line-derived Neurotrophic Factor (gdnf) on Mouse Fetal Ventral Mesencephalic Tissue
The symptoms of Parkinson's disease occur due to degeneration of dopamine neurons in substantia nigra. It has been demonstrated that glial cell line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor when it comes to protect and enhance survival of dopamine neurons in animal models of Parkinson's disease. The aim of this study was to evaluate shortand long-term effects of GDNF o...
متن کاملکلون کردن cdnaیneurotrophic factor)gdnf(glial cell line-derived در حامل بیانی با قابلیت الحاق هدفمند در ژنوم سلول میزبان
چ فده قیقحت : هدننک دک یلاوت زا یپک ود یاراد ینایب روتکو تخاس هعلاطم نیا زا فده gdnf نایب یارب یناسنا .تسا نارادناتسپ یلولس هدر رد : قیقحت شور cds نیئتورپ gdnf صخشم یکیتامروفناویب تاعلاطم هلیسو هب یناسنا دیدرگ تفج ود کمک اب . اب هک یرمیارپ رازفا مرن oligo7.4 یحارط دندش رد هناشن دیتپپ ، n و نیئتورپ لانیمرت his-tag رد c نآ لانیمرت شور زا هدافتسا اب .تفرگ رارق t/a cloning روتکو رد هدش دی...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1998
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)40409-5